PyPy is a python-focused project that builds a python-focused runtime. My comment was more about projects trying to retrofit Python on top of runtimes that were built for very different languages, typically because of some constraint that has now disappeared.
If the GIL is so important to you that you're willing to suffer the pain of running on another VM with a much-reduced ecosystem, while at the same time having requirements so complex that PyPy cannot meet them, maybe Python is just not the right tool for the project.
