Cooking blogs (I read a bunch more, but these are the best):

http://thestonesoup.com/blog/

http://smittenkitchen.com/

http://globaltableadventure.com/

A blog ostensibly about learning Japanese but really about learning anything:

http://www.alljapaneseallthetime.com/blog/

Humor:

http://www.qwantz.com/index.php

http://hyperboleandahalf.blogspot.com/

Programming:

http://prog21.dadgum.com/

Inspiration / business:

http://www.jamesaltucher.com/

http://unicornfree.com/

A little of everything:

http://jsomers.net/blog/