would you mind sharing what you think are the largest bottlenecks to (1) 24-hr turnaround and (2) CAR-T therapy for < $10K?

I think that's near impossible to achieve with an autologous product. To meet those two goals I think you'd need to have an allogenic product manufactured and QCd in advance in a large batch, which you could thaw and infuse on demand. The problem with that approach is histocompatibility (HLA) matching, but several companies are working on that.

thanks for sharing. this is such an impactful space. hopefully someone one day can lower the cost to $10K or ideally $1K.