I've been using it as well with great success.

A couple years ago I inherited about 100 Mac Pros that are part of $dayjob's CI infrastructure. They had been managed over the years using a combination of shell scripts, Chef, and manually via VNC. No two machines were alike. The Chef recipes had all bit-rotted and weren't usable and due to $reasons were based on an old version of Chef that $company was stuck on.

So I looked around for alternatives, and being most comfortable in Python, I explored Ansible, Salt, and Pyinfra.

Ansible seemed like the obvious choice, but it has very few playbooks/actions for macOS systems. I was going to have to write my own. As I dug into its documentation, I found it was taking me a long time to wrap my head around all that I needed to do and started to sour on its complexity. This is a matter of taste, but I just didn't find Ansible very welcoming. I wanted something simpler.

I had previously used Fabric, so considered using it again. But Fabric offers too little (it's really not much more than parallel ssh-if you want idempotent operations you have to write that yourself), and I don't agree with the direction it took with version 2.x.

Then I found Pyinfra. It took me less than 30 minutes to understand it in its entirety. It's conceptually simple: you have an inventory of machines that it connects to in parallel over ssh. You provide it with a deploy script that combines facts and operations. Pyinfra uses the deploy script to gather facts about each machine, then you use those facts to decide whether you need to perform any operations. It then performs those operations on each machine as needed. The inventory file, deploy script, facts, and operations are trivial to write for someone comfortable with Python. It's all Python with the facts and operations being decorated functions. There is no DSL to learn. (It comes with a bunch of pre-written facts and operations, but they are mostly for Linux systems. I had to mostly wrote my own for macOS, but I found them really easy to write.)

I had it operational the same day I found it. I used it to successfully get all of the Mac Pros into consistent state: things like system settings, installing Xcode, automating installs of brew packages all at the same version, installing JVMs, updating and upgrading macOS, installing Sentinel One, etc.

I've been very happy with it, even contributing a few PRs to fix small bugs and contribute minor functionality.

I would love to see any macOS facts/operation code if you can/would be willing to share! We also managed a bunch of macs using pyinfra but mostly stuck to shell commands.