> Strangely it seems to me that a lot of effort is going more into being able to simulate full cells that contain unknown mechanisms, rather than trying to use the capabilities to create hypothesis to uncover the unknown mechanisms. Yes, that probably expedites the path towards simulating much bigger human cells, but ultimately still leaves us in the dark on most fronts.
I imagine it's much easier to create and test hypotheses about the unknown mechanisms, when you can view them in context of a larger system, with reasonable performance, allowing you to metaphorically "grab them in your palm" and tweak on the fly. We work better when we explore things, instead of immediately taking on problems that are at the limit of our computational tools, requiring individual brains (and tons of paperwork) to make up for the difference.
In this sense, researching the nano-scale basics, and aiming to simulate micro-scale cellular systems, are actually aligned - as long as they're not cutting too much corners, the latter is creating space for former work to be done efficiently.
I imagine it's much easier to create and test hypotheses about the unknown mechanisms, when you can view them in context of a larger system, with reasonable performance, allowing you to metaphorically "grab them in your palm" and tweak on the fly. We work better when we explore things, instead of immediately taking on problems that are at the limit of our computational tools, requiring individual brains (and tons of paperwork) to make up for the difference.
In this sense, researching the nano-scale basics, and aiming to simulate micro-scale cellular systems, are actually aligned - as long as they're not cutting too much corners, the latter is creating space for former work to be done efficiently.